I don't know that I used FileMaker before, so I can't answer directly to that question, but to Excel, yes, very well, in fact. We use it to bulk scan bar codes into spread sheets we were able to code the scanner to insert a "tab" at the end of reading a bar code and it allows for the cell in Excel to be filled and then move to the next cell over to wait for the next code entered. In our case, we scan a case count (printed bar codes for case count standards like 1, 12, 24 ) and then we scan "enter". If FileMaker will allow you to use these kinds of code to manipulate fields for entry, then it should work for you there too. Hope it helps!